10 Epigenetic changes are also thought to contribute to the missing heritability. 8, 9 Epigenetic changes, in particular changes in DNA methylation (DNAm), reflect effects of environmental changes on the human genome and may underline the link between obesity and environmental factors. 7 It is widely recognized that environmental factors, such as lack of physical activity and increased energy intake, have been the driving force for the current obesity epidemic. 5 Although it is estimated that 40-70% of variability in body mass index (BMI), a common measure to assess general obesity, is explained by genetic factors, 6 only ~6% of variance in BMI is explained by genetic variants identified in the largest genome-wide association study to date. 1– 4 Etiology of human obesity is complex. Obesity is a major public health challenge due to its high prevalence and related adverse health consequences. ![]() Baseline BMI was associated with a DNAm score (calculated from DNAm levels at the associated CpG sites) at follow-up (P < 0.001 both in Blacks and in Whites). Cross-lagged panel analyses showed significant unidirectional paths (P FDR < 0.05) from baseline BMI to follow-up DNAm at 18 CpG sites in Whites and 7 in Blacks no CpG sites showed significant paths from DNAm at baseline to BMI at follow-up. ![]() In discovery and replication samples, 349 CpG sites (266 novel) in Whites and 36 (21 novel) in Blacks were identified to be robustly associated with BMI, with 8 (1 novel) CpG sites overlapping between the two races. Cross-lagged panel analysis was used to examine the temporal relationship between DNAm and BMI in 439 Whites and 201 Blacks who were examined twice 6.2 years apart. Suggestive CpG sites were further replicated in 252 Whites and 228 Blacks from the Georgia Stress and Heart Study. Listed by McKinley Properties, LLC.Race-specific EWASs were performed in 995 Whites and 490 Blacks from the Bogalusa Heart Study. Lot Features: Back Yard, Cul-De-Sac, Front Yard, Landscaped, Level, Private.Common Walls: 2+ Common Walls, No One Above, No One Below.Roof: Composition, Ridge Vents, Shingle.Construction: Brick Front, Cement Siding.Utility Description: Cable Available, Electricity Available, Natural Gas Available, Phone Available, Sewer Available, Underground Utilities, Water Available.Fees Include: Maintenance Grounds, Reserve Fund ( Next to Howard Brothers Ace Hardware ) Go approximately 1.5 miles to entrance on right. Driving Directions: Going north on Mundy Mill Rd.Parking Features: Garage, Garage Door Opener, Garage Faces Front, Kitchen Level, Level Driveway.Exterior Features: Private Front Entry, Private Rear Entry, Private Yard, Rain Gutters.Security/Safety: Carbon Monoxide Detector(s), Smoke Detector(s).Amenities: Homeowners Assoc, Near Schools, Near Shopping, Playground, Pool, Sidewalks, Street Lights.Kitchen: Stained Cabinets, Kitchen Island, Pantry, Solid Surface Counters, View to Family Room.Primary Bathroom: Double Vanity, Shower Only.Appliances: Dishwasher, Disposal, Gas Cooktop. ![]() Fireplace(s): Factory Built, Family Room, Gas Log, Gas Starter, Glass Doors.Interior Features: Cathedral Ceiling(s), Double Vanity, Entrance Foyer 2 Story, High Ceilings 9 ft Upper, High Ceilings 10 ft Main.
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